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Biosensor Publications
*DeMarco, D. R., E. W. Saaski, D. A. McCrae, and D. V. Lim. 1999. Rapid detection of Escherichia coli O157:H7 in ground beef using a fiber optic biosensor. J. Food Prot.:711-716. PDF
Lim, D.V. 2000. Rapid pathogen detection in the new millennium. NFPA Journal. 2:13-17. PDF
DeMarco, D. R., and D. V. Lim. 2001. Direct detection of Escherichia coli O157:H7 in unpasteurized apple juice with an evanescent wave biosensor. J. Rapid Meth. Auto. Microbiol. 9:241-257. PDF
Lim, D.V. 2001. Rapid biosensor detection of foodborne microbial pathogens. Microbiol. Meth. Forum Newsletter 18:13-17.
Tims T.B., Dickey S.S. DeMarco D.R., Lim D.V. 2001. Detection of low levels of Listeria monocytogenes within 20 hours using an evanescent wave biosensor. Am. Clin. Lab. 20:28-9. PDF
*DeMarco, D. R., and D. V. Lim. 2002. Detection of Escherichia coli O157:H7 in 10- and 25-gram ground beef samples with an evanescent-wave biosensor with silica and polystyrene waveguides. J. Food Prot.:596-602. PDF
Kramer, M. F., T. B. Tims, D. R. DeMarco, and D. V. Lim. 2002. Recovery of Escherichia coli O157:H7 from fiber optic waveguides used for rapid biosensor detection. J. Rapid Meth. Auto. Microbiol. 10:93-106. PDF
Tims, T. B., and D. V. Lim. 2003. Confirmation of viable E. coli O157:H7 by enrichment and PCR after rapid biosensor detection. J. Microbiol. Meth. 55:141-147. PDF
Lim, D. V. 2003. Detection of microorganisms and toxins with evanescent wave fiber-optic biosensors. Proc. IEEE 91:902-907. PDF
Lim, Daniel V. 2003. Real time/near real time detection of bioterrorism agents. Biodetection Technologies: Identification Innovations and Strategies, pp. 117-136. Knowledge Press, Brookline, MA.
*Kramer, M. F., and D. V. Lim. 2004. A rapid and automated fiber optic-based biosensor assay for the detection of Salmonella in spent irrigation water used in the sprouting of sprout seeds. J. Food Prot. 67:46-52. PDF
Donaldson, K. A., M. F. Kramer, and D. V. Lim. 2004. Detection of Vaccinia virus, a surrogate of the smallpox virus, from seeded throat culture swabs using a fiber optic biosensor assay. Biosensor. Bioelect. 20:322-327. PDF
Tims, T.B. and D.V. Lim. 2004. Rapid detection of Bacillus anthracis spores directly from powders with an evanescent wave fiber-optic biosensor. J. Microbiol. Methods 59:127-130. PDF
Simpson, J.M. and D.V. Lim. Rapid PCR Confirmation of E. coli O157:H7 after Evanescent Wave Fiber Optic Biosensor Detection. 2005. Biosensor. Bioelect. 21:881-887. PDF
Lim, D.V., J.M. Simpson, E.A. Kearns, and M.F. Kramer. 2005. Monitoring for Agents of Bioterrorism/Biowarfare. Clin. Microbiol. Rev. 18:583-607. PDF
Kramer, M.F., G. Vesey, N. L. Look, B. R. Herbert, J. M. Simpson-Stroot, and D. V. Lim. 2007. Development of a Cryptosporidium Oocyst Assay Using an Automated Fiber Optic Biosensor. J. Biol. Eng. 1:3. PDF
Simpson-Stroot, J. M., E. A. Kearns, P. G. Stroot, S. Magaña, and D. V. Lim. 2008. Monitoring Biosensor Capture Efficiencies: Development of a Model Using GFP-Expressing Escherichia coli O157:H7. J. Microbiol. Methods 72:29-37. PDF
Kearns, E.A., S. Magana, and D.V. Lim. 2008. Automated concentration and recovery of microorganisms from drinking water using dead-end ultrafiltration. J. Appl. Microbiol. 105:432-442. PDF
Leskinen, S.D. and D.V. Lim. 2008. Rapid ultrafiltration concentration and biosensor detection of enterococci from large volumes of Florida recreational water. Appl. Environ. Microbiol. 74:4792-4798. PDF
Denton, K.A., M.F. Kramer, and D.V. Lim. 2009. Rapid detection of Mycobacterium tuberculosis in lung tissue using a fiber optic biosensor. J. Rapid Meth. Automat. Microbiol. 16:439-453.
Lim, D. V., E. A. Kearns, S. D. Leskinen, S. Magaña, J. M. Stroot, D. M Hunter and S. M. Schlemmer. 2009. Sample Preparation and Assay Refinements for Pathogen Detection Platforms. SPIE - Frontiers in Pathogen Detection: From Nanosensors to Systems. Proc. of SPIE Vol. 7167.
Leskinen, S. D., S. M. Schlemmer, E. A. Kearns and D. V. Lim. 2009. Detection of E. coli O157:H7 in Complex Matrices under Varying FLow Parameters with a Robotic, Fluorometric Assay System. SPIE -Frontiers in Pathogen Detection: From Nanosensors to Systems. Proc. of SPIE Vol. 7167.
Leskinen, S. D. and D. V. Lim. 2009. Rapid dead-end ultrafiltration concentration and biosensor detection of enterococci from beach waters of Southern California. J. Water. Hlth. 7:674-684.
Antimicrobial Publications
Turos, E., M.I. Konaklieve, R. Ren, H. Shi, J. Gonzalez, S. Dickey, and D.V. Lim. 2000. N-thiolated bicyclic and monocyclic beta-lactams. Tetrahedron. 56:5571-5578. PDF
Turos, E., T.E. Long, M.I. Konaklieva, C. Coates, J-Y. Shim, S. Dickey, D.V. Lim, and A. Cannons. 2002. N-Thiolated ß-Lactams: Novel antimicrobial agents for methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Letts 12:2229-2231. PDF
Coates, C., T.E. Long, E. Turos, S. Dickey, and D.V. Lim. 2003. N-Thiolated ß-lactam antibacterials: Defining the role of unsaturation in the C4 side chain. Bioorg Med Chem 11:193-196. PDF
Long, T.E., E. Turos, M.I. Konaklieva, A. L. Blum, A. Amry, E.A. Baker, L.S. Suwandi, M.D. McCain, M.F. Rahman, S. Dickey, and D.V. Lim. 2003. Effect of aryl ring fluorination on the antibacterial properties of C4 aryl-substituted N-methylthio ß-lactams. Bioorg Med Chem 11:1859-1863. PDF
Turos, E., C. Coates, J.Y. Shim, Y. Wang, J.M. Leslie, T.E. Long, G.S.K. Reddy, A. Ortiz, M. Culbreath, S. Dickey, D.V. Lim, E. Alonso, and J. Gonzalez. 2005. N-Methylthio ß-lactam antibacterials: Effects of the C3/C4 ring substituents on anti-MRSA activity. Bioorg. Med. Chem. 13:6289-6308. PDF
Turos, E., R.K. Mishra, K.D. Revell, C.M. Coates, S. Dickey, and D.V. Lim. 2006. N-Thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus anthracis. Bioorg. Med. Chem. Lett. 16:2081-2083. PDF
Turos, E., T.E. Long, B. Heldreth, J.M. Leslie, S.K.R. Guntireddygari, Y. Wang, C. Coates, M. Konaklieva, S. Dickey, D.V Lim, E. Alonso, and J. Gonzalez. 2006. N-Thiolated ß-lactams: a new family of anti-Bacillus agents. Bioorg. Med. Chem. Lett. 16:2084-2090. PDF
Heldreth, B., T.E. Long, S. Jang, G.S.K. Reddy, E. Turos, S. Dickey, and D. V. Lim. 2006. N-Thiolated ß-lactam antibacterials: effects of the N-organothio substituent on anti-MRSA activity. Bioorg. Med. Chem. 14:3775-3784. PDF
Turos, E., J-Y. Shim, Y. Wang, K. Greenhalgh, G.S.K. Reddy, S. Dickey, and D.V. Lim. 2007. Antibiotic-conjugated polyacrylate nanoparticles: a new drug delivery platform for water-insoluble anti-MRSA agents. Bioorg. Med. Chem. Lett. 17:53-56. PDF
Turos, E., S.K. Reddy, K. Greenhalgh, S.A. Abeylath, S. Dickey, and D.V. Lim. 2007. Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA. Biorg. Med. Chem. Lett. 17:3468-3472. PDF
Abeylath, S.C., E. Turos, S. Dickey, and D.V. Lim. 2008. Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis. Bioorg. Med. Chem. 16:2412-2418. PDF
Turos, E., K.D. Revell, P. Ramaraju, D.A. Gergeres, K. Greenhalgh, A. Young, N. Sathyanarayan, S. Dickey, D.V. Lim, M.M. Alhamadsheh, K. Reynolds. 2008. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorg. Med. Chem. 16:6501-6508. PDF
O’Driscoll, M., K. Greenhalgh, A. Young, E. Turos, S. Dickey, and D.V. Lim. 2008. Studies on the antifungal properties of N-thiolated beta-lactams. Bioorg Med. Chem. 16:7832-7837. PDF
Garay-Jimenez, J. C., D. Gergeres, A. Young, S. Dickey, D. V. Lim, and E. Turos. 2009. Physical properties and biological activity fo poly(butyl acrylate-styrene) nanoparticle emulsions prepared with conventional and polymerizable surfactants. Nanomed.: Nanotech. Biol. Med. (in press)
Antibody Publications
Nyquist-Battie, C., L.E. Frank, D. Lund, and D.V. Lim. 2004. Optimization of a fluorescence sandwich enzyme-linked immunosorbent assay for detection of Escherichia coli O157:H7 in apple juice. J. Food Protect. 67:2756-2759. PDF
Nyquist-Battie, C., L. Mathias, L.E. Frank, D. Lund, and D.V. Lim. 2005. Antibody-based detection of acid-shocked, acid-adapted, and apple juice-incubated Escherichia coli O157:H7. J. Immunoassay and Immunochem. 26:259-271. PDF
Nyquist-Battie, C., L. Freeman, J.P.S. Soberano, D. Lund, E. Kearns, and D.V. Lim. 2007. Effects of chlorine injury, starvation and Colitag enrichment on sandwich enzyme-linked immunosorbent assay (sELISA) detection of Escherichia coli O157:H7. J. Immunoassay Immunochem. 28:371-383. PDF
Nyquist-Battie, C., L. Freeman, K. Leckband, S. Martinez, A. Ansley, D. Lund, and D.V. Lim. 2008. Antibody-based detection of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium grown in low-shear modeled microgravity. Micrograv. Sci. Technol. 20:23-28. PDF
Other Publications
Harwood, V.J., N.C. Delahoya, R.M. Ulrich, M.F. Kramer, J.E. Whitlock, J.R. Garey, and D.V. Lim. 2004. Molecular confirmation of Enterococcus faecalis and E. faecium from clinical, fecal and environmental sources. Letts. Appl. Microbiol. 38:476-482. PDF
Lian, W., S.A. Litherland, H. Badrane, W. Tang, D. Wu, H.V. Baker, P.A. Gulig, D.V. Lim, and S. Jin. 2004. Ultra-sensitive detection of biomolecules with fluorescent dye-doped nanoparticles. Anal. Biochem. 334:135-144. PDF
Brown, D.R., L.D. Wednland, G.J. Ortiz, M.F. Kramer, D.V. Lim, M.B. Brown, and P.A. Klein. 2008. Evanescent-wave biosensor for field serodiagnosis of tortoise mycoplasmosis. Vet. Immunol. Immunopathol. 124:322-331. PDF
* Reprinted with permission from Journal of Food Protection. Copyright held by the International Association for Food Protection, Des Moines, Iowa, U.S.A.